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      Are Uraemic Children Immunologically Compromised?

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          Background: Various immunological abnormalities leading to impaired immune status have been described in uraemic adults; however, few data are available for uraemic children. Methods: In this study, peripheral blood total lymphocyte count and lymphocyte subsets (CD3+, CD4+, CD8+, CD16+, CD20+) were evaluated, skin tests with PPD and Candida antigens were performed, and serum immunoglobulin (IgG, IgA, IgM) and complement (C3, C4) levels were measured in 30 children with end-stage renal failure (10 before dialysis, 10 on continuous ambulatory peritoneal dialysis, and 10 on haemodialysis) and the results compared with those of 15 healthy controls. Results: The data showed significant lymphopenia in predialysis and haemodialysis groups. No significant change was observed in the CD4+/CD8+ ratio or in the percentages of lymphocyte subsets in either group studied, while the absolute values of some lymphocyte subsets were significantly lower in all groups as compared with controls. In skin test evaluation, only the patients in the predialysis group showed a significantly decreased response to Candida antigen. The serum immunoglobulin levels were significantly decreased in the continuous ambulatory peritoneal dialysis group as compared with the control group. Conclusion: Our results, together with those of other paediatric studies, reported in the literature, suggest that uraemic children are not immunocompromised, though the effects of uraemia may cause some variation in their immune status.

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          Effect of Oral Levamisole Supplementation to Hepatitis B Vaccination on the Rate of Immune Response in Chronic Hemodialysis Patients


            Author and article information

            S. Karger AG
            25 July 2001
            : 88
            : 4
            : 379-381
            aNephrology and Dialysis Unit, Emergency Hospital, Ankara, and Departments of bPaediatric Nephrology, cPaediatric Immunology, and dPathology, University of Ankara Medical School, Ankara, Turkey
            46024 Nephron 2001;88:379–381
            © 2001 S. Karger AG, Basel

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            Tables: 2, References: 15, Pages: 3
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            Short Communication

            Cardiovascular Medicine, Nephrology

            Children, Uraemia, Immune status


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