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      Dose-related effects of γ-amino β-hydroxy butyric acid (GABOB) infusion on growth hormone secretion in normal women

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          Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.

          A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.
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            Receptor activity and turnover of dopamine and noradrenaline after neuroleptics

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              Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans.

              A dose of 2.5 g of gamma-hydroxybutyric acid (GHB) was administered intravenously to 6 healthy male volunteers. A significant increase in plasma GH was observed at 30, 45, 60 and 90 min after injection. The plasma prolactin level increased significantly at 45 and 60 min after GHB injection. These responses were not found after the saline vehicle injection in the same subjects. It is conceivable that GHB could modify the release of serotonin from the nerve terminals and then stimulate the release of GH and prolactin.
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                Author and article information

                Journal
                Journal of Endocrinological Investigation
                J Endocrinol Invest
                Springer Nature
                0391-4097
                1720-8386
                March 1982
                April 11 2014
                March 1982
                : 5
                : 2
                : 101-106
                Article
                10.1007/BF03350499
                a9bd8543-4321-420c-bd01-9a2bbb1800db
                © 1982
                History

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