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      Regulations of Vasculatropin/Vascular Endothelial Growth Factor Bioavailability

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          Abstract

          Angiogenesis is a key step in organ development and remodelling during embryogenesis or tissue regeneration. Some pathological events such as tumor growth or diabetic retinopathy also lead to angiogenesis formation. Several molecules have already been identified as promoting angiogenesis in vivo. We have recently purified a new angiogenic growth factor. Its unique specificity for vascular endothelial cells led us to provisionally name it vasculotropin (VAS) or vascular endothelial growth factor (VEGF) or vascular permeability factor (VPF). In vitro, despite a moderate action on proliferation, VAS/VEGF strongly stimulates cell migration. In vivo, VAS/VEGF is a potent inducer of angiogenesis and vascular permeability. Its central role in angiogenesis is emphasized by the observation that its immunoneutralization prevents tumor progression.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6037-5
          978-3-318-00054-2
          1663-2818
          1663-2826
          1994
          1994
          05 December 2008
          : 42
          : 1-2
          : 14-19
          Affiliations
          aLaboratoire de Biologie Moléculaire de Eucaryotes, CNRS UPR, et bLaboratoire d’Endocrinologie Expérimentale, INSERM U-397, Bat L3, Hôpital Rangueil, Toulouse, France
          Article
          184138 Horm Res 1994;42:14–19
          10.1159/000184138
          7959629
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Growth Factors in Endocrinology: Recent Advances, Therapeutic Prospects

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