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AA-amyloidosis in dogs: partial amino acid sequence of protein AA and immunohistochemical cross-reactivity with human and cow AA-amyloid.

Comparative biochemistry and physiology. B, Comparative biochemistry

Species Specificity, Amino Acid Sequence, Amyloid, isolation & purification, Amyloidosis, metabolism, pathology, veterinary, Animals, Cattle, Cattle Diseases, Dog Diseases, Dogs, Humans, Kidney, Serum Amyloid A Protein

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      Protein AA was purified from the kidneys of dogs with spontaneous reactive amyloidosis. The protein had a blocked N-terminal. Sequence analysis of a peptide obtained after cyanogen bromide cleavage revealed an amino acid sequence corresponding to positions 24-42 of human AA. This region showed a strong homology to protein AA of other species. Antiserum to both human and dog protein AA reacted immunohistochemically with AA amyloid of human, dog and cow origin.

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