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      Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache

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          Abstract

          Background

          Chronic post-traumatic headache (PTH) is one of the most common symptoms of mild traumatic brain injury (mTBI) but its underlying mechanisms remain unknown. Inflammatory degranulation of dural mast cells (MCs) is thought to promote headache, and may play a role in PTH. Whether mTBI is associated with persistent degranulation of dural MCs is yet to be determined.

          Methods

          Histochemistry was used to evaluate time course changes in dural MC density and degranulation level in concussive head trauma and blast mouse models of mTBI. The effects of sumatriptan and the MC stabilizer cromolyn sodium on concussion-evoked dural MC degranulation were also investigated.

          Results

          Concussive head injury evoked persistent MC degranulation for at least 30 days. Blast trauma gave rise to a delayed MC degranulation response commencing at seven days that also persisted for at least 30 days. Neither sumatriptan nor cromolyn treatment reduced concussion-evoked persistent MC degranulation.

          Conclusions

          mTBI evoked by closed head injury or blast exposure is associated with persistent dural MC degranulation. Such a response in mTBI patients may contribute to PTH. Amelioration of PTH by sumatriptan may not involve inhibition of dural MC degranulation. If persistent dural MC degranulation contributes to PTH, then cromolyn treatment may not be effective.

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          Author and article information

          Journal
          8200710
          2844
          Cephalalgia
          Cephalalgia
          Cephalalgia : an international journal of headache
          0333-1024
          1468-2982
          4 May 2017
          12 November 2015
          September 2016
          07 July 2017
          : 36
          : 10
          : 915-923
          Affiliations
          [1 ]Department of Anesthesia Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, USA
          [2 ]Harvard Medical School, USA
          [3 ]Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Israel
          [4 ]Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Israel
          [5 ]Sagol School of Neuroscience, Tel Aviv University, Israel
          Author notes
          Corresponding author: Dr. Dan Levy, Department of Anesthesia, Critical Care, and Pain medicine, 330 Brookline Avenue/DA719, Boston MA 02215, USA. dlevy1@ 123456bidmc.harvard.edu
          Article
          PMC5500910 PMC5500910 5500910 nihpa775023
          10.1177/0333102415617412
          5500910
          26566937
          a9e37055-fa05-4062-9f9d-4f522a34e307

          Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0333102415617412

          History
          Categories
          Article

          concussion,posttraumatic headache,dura,mast cell,mouse,blast,Minimal traumatic brain injury

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