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      Does a learned taste aversion contribute to the anorectic effect of bacterial lipopolysaccharide?

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      Physiology & Behavior
      Elsevier BV

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          Abstract

          The present study addressed the possible role of a conditioned taste aversion in the anorectic effect of bacterial lipopolysaccharide (LPS) in the rat. Pairing an intraperitoneal (IP) injection of LPS (100 micrograms/kg b.wt.) with the subsequent presentation of a familiar diet (FD) or of a novel-tasting saccharin diet (SD) for several hours did not affect FD or SD intake when the same diet was offered several days later after 12 h of food deprivation. However, food intake during the second presentation of SD was reduced when food was not withheld prior to the test. In a similarly designed experiment, the antipyretic and antiinflammatory drug indomethacin (5 mg/kg b.wt., IP) attenuated the anorectic effect of LPS during the initial pairing, but did not affect the inhibition of SD intake in LPS-pretreated rats during the second feeding test. The antiemetic trimethobenzamide (5 mg/kg b.wt., IP) failed to influence the anorectic effect of LPS. Lesion of the area postrema (AP) and the adjacent nucleus of the solitary tract (NST) was found to enhance the anorectic effect of LPS, but the development of tolerance to this effect remained unchanged in AP/NST-lesioned animals. In spite of the ability of LPS to induce a taste aversion that inhibits feeding under certain conditions (novel-tasting diet, no food deprivation prior to the feeding test), the findings indicate that a learned taste aversion is not the only contributor to the anorectic effect of LPS.

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          Author and article information

          Journal
          Physiology & Behavior
          Physiology & Behavior
          Elsevier BV
          00319384
          November 1993
          November 1993
          : 54
          : 5
          : 961-966
          Article
          10.1016/0031-9384(93)90309-4
          8248390
          a9f4ae04-2e0b-4089-9c8a-b1a1d03cdab6
          © 1993

          https://www.elsevier.com/tdm/userlicense/1.0/

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