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      Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.

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          Abstract

          Mesenchymal stem cells (MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various components of the marrow microenvironment, such as bone, adipose, and stromal tissues. The bone marrow microenvironment is vital to the development, differentiation, and regulation of the lymphohematopoietic system. We hypothesized that the activities of MSCs in the bone marrow microenvironment might also include immunomodulatory effects on lymphocytes.

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          Author and article information

          Journal
          Exp Hematol
          Experimental hematology
          Elsevier BV
          0301-472X
          0301-472X
          Jan 2002
          : 30
          : 1
          Affiliations
          [1 ] University of Illinois, Chicago 60607, USA. ambart@uic.edu
          Article
          S0301472X0100769X
          10.1016/s0301-472x(01)00769-x
          11823036
          a9f5dcca-be6a-4b8a-859e-ea5027c99d3e
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