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      ID3 Promotes Stem Cell Features and Predicts Chemotherapeutic Response of Intrahepatic Cholangiocarcinoma

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          Most cited references41

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          Wnt signalling and its impact on development and cancer.

          The Wnt signalling pathway is an ancient system that has been highly conserved during evolution. It has a crucial role in the embryonic development of all animal species, in the regeneration of tissues in adult organisms and in many other processes. Mutations or deregulated expression of components of the Wnt pathway can induce disease, most importantly cancer. The first gene to be identified that encodes a Wnt signalling component, Int1 (integration 1), was molecularly characterized from mouse tumour cells 25 years ago. In parallel, the homologous gene Wingless in Drosophila melanogaster, which produces developmental defects in embryos, was characterized. Since then, further components of the Wnt pathway have been identified and their epistatic relationships have been defined. This article is a Timeline of crucial discoveries about the components and functions of this essential pathway.
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            Cholangiocarcinoma.

            Cholangiocarcinoma represents a diverse group of epithelial cancers united by late diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are undertaken for cholangiocarcinomas of different anatomical locations (intrahepatic, perihilar, and distal). Mixed hepatocellular cholangiocarcinomas have emerged as a distinct subtype of primary liver cancer. Clinicians need to be aware of intrahepatic cholangiocarcinomas arising in cirrhosis and properly assess liver masses in this setting for cholangiocarcinoma. Management of biliary obstruction is obligatory in perihilar cholangiocarcinoma, and advanced cytological tests such as fluorescence in-situ hybridisation for aneusomy are helpful in the diagnosis. Liver transplantation is a curative option for selected patients with perihilar but not with intrahepatic or distal cholangiocarcinoma. International efforts of clinicians and scientists are helping to identify the genetic drivers of cholangiocarcinoma progression, which will unveil early diagnostic markers and direct development of individualised therapies. Copyright © 2014 Elsevier Ltd. All rights reserved.
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              Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma.

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                Author and article information

                Journal
                Hepatology
                Hepatology
                Wiley
                0270-9139
                1527-3350
                February 27 2019
                May 2019
                March 08 2019
                May 2019
                : 69
                : 5
                : 1995-2012
                Affiliations
                [1 ]Department of Liver Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China
                [2 ]Department of General Surgery The First Affiliated Hospital, Nanjing Medical University Nanjing China
                [3 ]Shanghai Key Laboratory for Molecular Imaging Collaborative Research Center, Shanghai University of Medicine & Health Science Shanghai China
                Article
                10.1002/hep.30404
                30520117
                a9f8f3a6-3942-417c-aa09-e16261e0566f
                © 2019

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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