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      Neuronal subtype specification in the cerebral cortex.

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          Abstract

          In recent years, tremendous progress has been made in understanding the mechanisms underlying the specification of projection neurons within the mammalian neocortex. New experimental approaches have made it possible to identify progenitors and study the lineage relationships of different neocortical projection neurons. An expanding set of genes with layer and neuronal subtype specificity have been identified within the neocortex, and their function during projection neuron development is starting to be elucidated. Here, we assess recent data regarding the nature of neocortical progenitors, review the roles of individual genes in projection neuron specification and discuss the implications for progenitor plasticity.

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          Author and article information

          Journal
          Nat Rev Neurosci
          Nature reviews. Neuroscience
          Springer Science and Business Media LLC
          1471-003X
          1471-003X
          Jun 2007
          : 8
          : 6
          Affiliations
          [1 ] MGH-HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
          Article
          nrn2151
          10.1038/nrn2151
          17514196
          a9f98c9a-3a8f-43da-8d0d-f17e353e5494
          History

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