MeIQx (2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline), a carcinogenic heterocyclic
amine, was found to be present in dialysis fluid of 8 patients with uremia, but not
in fresh dialysis fluid before dialysis treatment. Concentrations of MeIQx in dialysates
ranged from 14 to 32 pM. The mean absolute contents of MeIQx in dialysates (6 to 40
liters) was 334 p mole. These results indicate that the carcinogenic heterocyclic
amine is present in the plasma of all patients with uremia.