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      An investigation of polymorphism in the interleukin-10 gene promoter.

      European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

      Cells, Cultured, Cytokines, genetics, Gene Expression Regulation, immunology, Gene Frequency, Humans, Interleukin-10, biosynthesis, Lymphocytes, Molecular Sequence Data, Polymorphism, Genetic, Promoter Regions, Genetic, Sequence Analysis, DNA

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          Abstract

          Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

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          9043871

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