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Liver enzyme alteration: a guide for clinicians.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

blood, Alanine Transaminase, Alkaline Phosphatase, Aspartate Aminotransferases, Bilirubin, Female, Humans, Liver, enzymology, Liver Diseases, diagnosis, Liver Function Tests, Male, Prothrombin Time, Reference Values, Serum Albumin, analysis, gamma-Glutamyltransferase

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      Abstract

      Isolated alterations of biochemical markers of liver damage in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.

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      15684121
      545762
      10.1503/cmaj.1040752

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