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      Effects of MK-196 on Urate and Electrolyte Excretion in the Rat

      , ,

      Nephron

      S. Karger AG

      Micropuncture, Diuretics, Uricosurics

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          Abstract

          Clearance and micropuncture techniques were used to evaluate the effects of MK-196 on uric acid and electrolyte excretion by the rat kidney. The urinary excretion of sodium, uric acid, calcium and magnesium increased significantly following MK-196 administration. The major site of action with respect to sodium reabsorption was in the ascending limb of Henle’s loop as revealed by depression of both free-water clearance and reabsorption. By contrast, microinjection studies with [2–14C]-urate revealed the major site of altered urate absorption to be in the proximal convoluted tubule, a site where sodium and water reabsorption was unchanged.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-3002-6
          978-3-318-00118-1
          1660-8151
          2235-3186
          1979
          1979
          02 December 2008
          : 23
          : Suppl 1
          : 21-24
          Affiliations
          Renal Section, Department of Medicine, Veterans Administration Hospital and Baylor College of Medicine, Houston, Tex.
          Article
          181663 Nephron 1979;23:21–24
          10.1159/000181663
          471148
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

          Uricosurics, Micropuncture, Diuretics

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