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      Membranous nephropathy: an IgG4-mediated disease.

      Lancet
      Animals, Antigen-Antibody Complex, metabolism, Basement Membrane, immunology, Glomerulonephritis, Membranous, Humans, Immunoglobulin G, Rats

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          Abstract

          Membranous nephropathy is characterised by the deposition of immunoglobulin, predominantly of the IgG4 subclass, along the epithelial surface of the glomerular-basement membrane. Current models of pathogenesis usually assume in-situ immune-complex formation involving an as yet uncharacterised fixed glomerular antigen. I argue that the properties of IgG4 (inability to fix complement and therefore impaired clearance of IgG4-containing complexes; low affinity and therefore ability for IgG4-containing complexes to dissociate and traverse the glomerular-basement membrane) are compatible with a pathogenic mechanism that involves the deposition of circulating IgG4 immune complexes containing diverse antigens.

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          Author and article information

          Journal
          9500350
          10.1016/S0140-6736(97)04122-6

          Chemistry
          Animals,Antigen-Antibody Complex,metabolism,Basement Membrane,immunology,Glomerulonephritis, Membranous,Humans,Immunoglobulin G,Rats

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