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      Prevention of Increases in Blood Pressure and Left Ventricular Mass and Remodeling of Resistance Arteries in Young New Zealand Genetically Hypertensive Rats: The Effects of Chronic Treatment with Valsartan, Enalapril and Felodipine

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          The relative efficacy of three antihypertensive drugs in the prevention of further elevation of blood pressure (BP) and cardiovascular structural remodeling in 4-week-old genetically hypertensive (GH) rats was studied by means of two complementary methods, stereology and myography. Four to 10-week-old GH rats were treated with valsartan (10 mg/kg/day), enalapril (10 mg/kg/day) or felodipine (30 mg/kg/day). Untreated GH and normotensive control rats of Wistar origin served as controls. Tail-cuff systolic SBP was measured weekly and left ventricular (LV) mass determined at the end of the experiment. Mesenteric resistance arteries (MRA) were either fixed by perfusion, embedded in Technovit and sections stained for stereological analysis, or mounted on a wire myograph for structural and functional measurements. BP and LV mass were significantly reduced by all drugs; decreases in BP and LV mass were smaller after felodipine treatment. Valsartan and enalapril caused a decrease in BP to normotensive control values. Felodipine kept BP at the 4-week level and prevented further rise with age. Valsartan caused hypotrophic outward remodeling of MRA, enalapril eutrophic outward remodeling and felodipine hypotrophic remodeling. Myograph measurements showed remodeling of the same order. While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.

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          Effects of long-term antihypertensive treatment with lisinopril on resistance arteries in hypertensive patients with left ventricular hypertrophy.

          To evaluate the effects of long-term antihypertensive therapy with the angiotensin converting enzyme inhibitor lisinopril on structural alterations and the endothelial function of small resistance arteries in hypertensive patients with left ventricular hypertrophy.
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            Structural changes of small resistance arteries in spontaneously hypertensive rats after treatment with various doses of lacidipine


              Author and article information

              J Vasc Res
              Journal of Vascular Research
              S. Karger AG
              April 2000
              31 March 2000
              : 37
              : 2
              : 134-145
              Department of Pharmacology, University of Otago, School of Medical Sciences, Dunedin, New Zealand
              25724 J Vasc Res 2000;37:134–145
              © 2000 S. Karger AG, Basel

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              Page count
              Figures: 3, Tables: 4, References: 43, Pages: 12
              Research Paper


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