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      Biodegradable pH-responsive hydrogels for controlled dual-drug release

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          Abstract

          pH-Responsive biodegradable hydrogels based on NIPAM/AA and a PLLA/PEG macro-crosslinker demonstrated pH mediated differential release of doxorubicin and tetracycline.

          Abstract

          Dual-drug loaded pH-responsive hydrogels were prepared as a delivery system carrying, as exemplars, both anti-cancer and anti-bacterial agents for pH controlled drug release. The hydrogels were composed of poly( l-lactide)- co-polyethyleneglycol- co-poly( l-lactide) dimethacrylates (with various molecular weights of l-lactide oligomers) as a macromolecular crosslinker and copolymerized with acrylic acid and N-isopropylacrylamide. The biodegradability, biocompatibility and mechanical properties of the hydrogels were characterized with the hydrogels being nontoxic to cells, while showing a reversible >80% reduction in volume at pH 1.2 compared to pH 7.4. Drug release profiles showed differential release of tetracycline over doxorubicin at pH 1.2, with both drugs being released equally at pH 7.4. Biodegradability was tunable by altering the crosslinking density and pH, with the total degradation of the best gels observed within 2 weeks at pH 7.4.

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          Most cited references44

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          Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.

          Biodegradable nano/microparticles of poly(D,L-lactide-co-glycolide) (PLGA) and PLGA-based polymers are widely explored as carriers for controlled delivery of macromolecular therapeutics such as proteins, peptides, vaccines, genes, antigens, growth factors, etc. These devices are mainly produced by emulsion or double-emulsion technique followed by solvent evaporation or spray drying. Drug encapsulation, particle size, additives added during formulation, molecular weight, ratio of lactide to glycolide moieties in PLGA and surface morphology could influence the release characteristics. Encapsulation efficiency and release rates through nano/microparticle-mediated drug delivery devices can be optimized to improve their therapeutic efficacy. In this review, important findings of the past decade on the encapsulation and release profiles of macromolecular therapeutics from PLGA and PLGA-based nano/microparticles are discussed critically in relation to nature and type of bioactive molecule, carrier polymer and experimental variables that influence the delivery of macromolecular therapeutics. Even though extensive research on biodegradable microparticles containing macromolecular drugs has greatly advanced to the level of production know-how, the effects of critical parameters influencing drug encapsulation are not sufficiently investigated for nano-scaled carriers. The present review attempts to address some important data on nano/microparticle-based delivery systems of PLGA and PLGA-derived polymers with reference to macromolecular drugs.
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            Magnetic Hydrogels and Their Potential Biomedical Applications

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              Light-Responsive Block Copolymer Micelles

              Yue Zhao (2012)
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                Author and article information

                Journal
                JMCBDV
                Journal of Materials Chemistry B
                J. Mater. Chem. B
                Royal Society of Chemistry (RSC)
                2050-750X
                2050-7518
                2018
                2018
                : 6
                : 3
                : 510-517
                Affiliations
                [1 ]Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials
                [2 ]School of Materials Science and Engineering
                [3 ]Changzhou University
                [4 ]Changzhou 213164
                [5 ]China
                [6 ]Institute of Biomedical Engineering and Health Sciences
                [7 ]Department of Plastic and Aesthetic Surgery
                [8 ]The Affiliated Second People's Hospital of Changzhou
                [9 ]Nanjing Medical University
                [10 ]Changzhou 213003
                [11 ]School of Chemistry
                [12 ]EaStCHEM
                [13 ]University of Edinburgh
                [14 ]Edinburgh
                [15 ]UK
                Article
                10.1039/C7TB01851G
                32254530
                aa87fdb0-e879-488b-ba91-dd479da7c7aa
                © 2018

                http://rsc.li/journals-terms-of-use

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