Lifestyle modification is essential to improve quality of life among patients with coronary artery disease. However, it is one of the challenges for patients with coronary artery disease. The aim of the study to assess the adherence level and factors affecting lifestyle modifications. A cross-sectional study among 113 patients was conducted using a self-administered questionnaire. The findings of the study indicated that the level of adherence to lifestyle modification was low 2.09(±.19). The sociodemographic and clinical characteristics significantly affected lifestyle modification (p<.001). This study found factors affecting lifestyle modification that essential to initiate development interventions to improve quality of life.