Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm

Lascarrou, Jean-Baptiste; Merdji, Hamid; Le Gouge, Amélie; Colin, Gwenhael; Grillet, Guillaume; Girardie, Patrick; Coupez, Elisabeth; Dequin, Pierre-François; Cariou, Alain; Boulain, Thierry; Brule, Noëlle; Frat, Jean-Pierre; Asfar, Pierre; Pichon, Nicolas; Landais, Mickael; Plantefeve, Gaétan; Quenot, Jean-Pierre; Chakarian, Jean-Charles; Sirodot, Michel; Legriel, Stephane; Letheulle, Julien; Thevenin, Didier; Desachy, Arnaud; Delahaye, Arnaud; Botoc, Vlad; Vimeux, Sylvie; Martino, Frédéric; Giraudeau, Bruno; Reignier, Jean

doi:10.1056/NEJMoa1906661

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Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm

Author(s): Jean-Baptiste Lascarrou ¹ , Hamid Merdji ¹ , Amélie Le Gouge ¹ , Gwenhael Colin ¹ , Guillaume Grillet ¹ , Patrick Girardie ¹ , Elisabeth Coupez ¹ , Pierre-François Dequin ¹ , Alain Cariou ¹ , Thierry Boulain ¹ , Noelle Brule ¹ , Jean-Pierre Frat ¹ , Pierre Asfar ¹ , Nicolas Pichon ¹ , Mickael Landais ¹ , Gaëtan Plantefeve ¹ , Jean-Pierre Quenot ¹ , Jean-Charles Chakarian ¹ , Michel Sirodot ¹ , Stéphane Legriel ¹ , Julien Letheulle ¹ , Didier Thevenin ¹ , Arnaud Desachy ¹ , Arnaud Delahaye ¹ , Vlad Botoc ¹ , Sylvie Vimeux ¹ , Frederic Martino ¹ , Bruno Giraudeau ¹ , Jean Reignier ¹

Publication date Created: October 02 2019

Publication date (Electronic): October 02 2019

Journal: New England Journal of Medicine

Publisher: Massachusetts Medical Society

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Abstract

Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate therapeutic hypothermia in patients with nonshockable rhythms (asystole or pulseless electrical activity) is debated.

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A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest

Kyee Han, Nigel Stallard, Stavros Petrou … (2018)

Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest led the International Liaison Committee on Resuscitation to call for a placebo-controlled trial to determine whether the use of epinephrine is safe and effective in such patients.

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Author and article information

Journal

Title: New England Journal of Medicine

Abbreviated Title: N Engl J Med

Publisher: Massachusetts Medical Society

ISSN (Print): 0028-4793

ISSN (Electronic): 1533-4406

Publication date Created: October 02 2019

Publication date (Electronic): October 02 2019

Affiliations

[1 ]From Médecine Intensive Réanimation, University Hospital Center, Nantes (J.-B.L., N.B., J.R.), the Paris Cardiovascular Research Center, INSERM Unité 970 (J.-B.L., A.C.), the Medical Intensive Care Unit, Cochin University Hospital Center (A.C.), and the AfterROSC Network (J.-B.L., A.C., N.P., S.L.), Paris, Université de Strasbourg, Faculté de Médecine (H.M.), Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Service de Médecine Intensive Réanimation (H.M.), and Unité Mixte de Recherche (UMR)...