Abstract. This exploratory study tests whether zinc is related to C-reactive protein (CRP) and cortisol concentrations in major depressive disorder (MDD). Plasma zinc, salivary CRP, and plasma cortisol concentrations were studied in 20 treatment-naïve MDD patients and 20 controls. No differences in zinc and CRP were observed with higher cortisol (p = 0.01) in MDD. No correlations were seen between zinc and CRP or cortisol in MDD or controls. Positive correlation was found between cortisol and CRP both in MDD (p < 0.01) and controls (p < 0.01). These results support evidence linking hypercortisolemia and inflammation in MDD with no zinc abnormalities at an early stage of the disease.