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Zinc, C-reactive protein, and cortisol in major depressive disorder: an exploratory analysis

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      Abstract

      Abstract. This exploratory study tests whether zinc is related to C-reactive protein (CRP) and cortisol concentrations in major depressive disorder (MDD). Plasma zinc, salivary CRP, and plasma cortisol concentrations were studied in 20 treatment-naïve MDD patients and 20 controls. No differences in zinc and CRP were observed with higher cortisol (p = 0.01) in MDD. No correlations were seen between zinc and CRP or cortisol in MDD or controls. Positive correlation was found between cortisol and CRP both in MDD (p < 0.01) and controls (p < 0.01). These results support evidence linking hypercortisolemia and inflammation in MDD with no zinc abnormalities at an early stage of the disease.


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      Copper and carcinogenesis.

      Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper, because of its mobilization and redox activity, is believed to play a central role in the formation of reactive oxygen species (ROS), such as O2-* and *OH radicals, that bind very fast to DNA, and produce damage by breaking the DNA strands or modifying the bases and/or deoxyribose leading to carcinogenesis. The chemistry and biochemistry of copper is briefly accounted together with its involvement in cancer and other diseases.
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        Serum ceruloplasmin and copper levels in patients with primary brain tumors.

        Serum copper and ceruloplasmin levels are known to increase in several malignancies such as osteosarcomas, some gastrointestinal tumors, and lung cancer. In this study serum copper and ceruloplasmin levels in 40 patients with primary brain tumors were studied. Both parameters were increased in sera of patients with tumors in comparison with healthy subjects or patients with non-tumorous neurological diseases. It is concluded that copper and ceruloplasmin represent a good complement to some other nonspecific parameters in evaluating the activity of malignancy and the therapeutic results.
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          Interleukin 7 is produced by murine and human keratinocytes

          Interleukin 7 (IL-7) was originally identified as a growth factor for B cell progenitors, and subsequently has been shown to exert proliferative effects on T cell progenitors and mature peripheral T cells as well. Constitutive IL-7 mRNA expression so far had been demonstrated in bone marrow stromal cell lines, thymus, spleen, and among nonlymphoid tissues in liver and kidney. Here we show that both murine and human keratinocytes express IL-7 mRNA and release IL-7 protein in biologically relevant amounts. The physiological or pathological relevance of keratinocyte-derived IL-7 is presently unknown. Our finding that keratinocytes can produce IL-7 in concert with reports that IL-7 is a growth factor for in vivo primed antigen- specific T cells, as well as for T lymphoma cells suggests, however, that keratinocyte-derived IL-7 is important in the pathogenesis of inflammatory skin diseases and cutaneous T cell lymphoma.
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            Author and article information

            Journal
            Trace Elements and Electrolytes
            TE
            Dustri-Verlgag Dr. Karl Feistle
            0946-2104
            2017
            July 01 2017
            : 34
            : 07
            : 104-106
            10.5414/TEX01461
            © 2017
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