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      Iron deficiency and brain development.

      1 ,
      Seminars in pediatric neurology
      Elsevier BV

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          Abstract

          Iron deficiency (ID) is common in pregnant women and infants worldwide. Rodent models show that ID during gestation/lactation alters neurometabolism, neurotransmitters, myelination, and gene/protein profiles before and after iron repletion at weaning. Human infants with iron deficiency anemia test lower in cognitive, motor, social-emotional, and neurophysiologic development than comparison group infants. Iron therapy does not consistently improve developmental outcome, with long-term differences observed. Poorer outcome has also been shown in human and monkey infants with fetal/neonatal ID. Recent randomized trials of infant iron supplementation show benefits, indicating that adverse effects can be prevented and/or reversed with iron earlier in development or before ID becomes severe or chronic. This body of research emphasizes the importance of protecting the developing brain from ID.

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          Author and article information

          Journal
          Semin Pediatr Neurol
          Seminars in pediatric neurology
          Elsevier BV
          1071-9091
          1071-9091
          Sep 2006
          : 13
          : 3
          Affiliations
          [1 ] Center for Human Growth and Development, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109-0406, USA. blozoff@umich.edu
          Article
          S1071-9091(06)00103-3
          10.1016/j.spen.2006.08.004
          17101454
          aad231c3-3068-4967-bab2-fabce10b1e06
          History

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