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      An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

      , , , , ,
      Current Biology
      Elsevier BV

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          Abstract

          Size regulation is fundamental in developing multicellular organisms and occurs through the control of cell number and cell size. Studies in Drosophila have identified an evolutionarily conserved signaling pathway that regulates organismal size and that includes the Drosophila insulin receptor substrate homolog Chico, the lipid kinase PI(3)K (Dp110), DAkt1/dPKB, and dS6K. We demonstrate that varying the activity of the Drosophila insulin receptor homolog (DInr) during development regulates organ size by changing cell size and cell number in a cell-autonomous manner. An amino acid substitution at the corresponding position in the kinase domain of the human and Drosophila insulin receptors causes severe growth retardation. Furthermore, we show that the Drosophila genome contains seven insulin-like genes that are expressed in a highly tissue- and stage-specific pattern. Overexpression of one of these insulin-like genes alters growth control in a DInr-dependent manner. This study shows that the Drosophila insulin receptor autonomously controls cell and organ size, and that overexpression of a gene encoding an insulin-like peptide is sufficient to increase body size.

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          Author and article information

          Journal
          Current Biology
          Current Biology
          Elsevier BV
          09609822
          February 2001
          February 2001
          : 11
          : 4
          : 213-221
          Article
          10.1016/S0960-9822(01)00068-9
          11250149
          aada0359-2ca6-4258-8d5f-e17133e40822
          © 2001

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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