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      Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.

      1 ,
      Nature reviews. Neuroscience
      Springer Science and Business Media LLC

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          Abstract

          The majority of functional neuroscience studies have focused on the brain's response to a task or stimulus. However, the brain is very active even in the absence of explicit input or output. In this Article we review recent studies examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity. Although several challenges remain, these studies have provided insight into the intrinsic functional architecture of the brain, variability in behaviour and potential physiological correlates of neurological and psychiatric disease.

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          Author and article information

          Journal
          Nat Rev Neurosci
          Nature reviews. Neuroscience
          Springer Science and Business Media LLC
          1471-003X
          1471-003X
          Sep 2007
          : 8
          : 9
          Affiliations
          [1 ] Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, Missouri 63110, USA. foxm@npg.wustl.edu
          Article
          nrn2201
          10.1038/nrn2201
          17704812
          aae92bb9-1223-4ed2-befc-1c157f786abd
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