Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400.

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Abstract

This paper describes recommended methods for the use of event-related brain potentials (ERPs) in clinical research and reviews applications to a variety of psychiatric and neurological disorders. Techniques are presented for eliciting, recording, and quantifying three major cognitive components with confirmed clinical utility: mismatch negativity (MMN), P300, and N400. Also highlighted are applications of each of the components as methods of investigating central nervous system pathology. The guidelines are intended to assist investigators who use ERPs in clinical research, in an effort to provide clear and concise recommendations and thereby to standardize methodology and facilitate comparability of data across laboratories.

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Journal

Journal ID (iso-abbrev): Clin Neurophysiol

Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Publisher: Elsevier BV

ISSN (Electronic): 1872-8952

ISSN (Print): 1388-2457

Publication date (Electronic): Nov 2009

Volume: 120

Issue: 11

Affiliations

[1 ] Clinical Psychophysiology and Psychopharmacology Laboratory, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address: cduncan@usuhs.mil.

[2 ] School of Psychology and Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia.

[3 ] Department of Linguistics and Languages, McMaster University, Hamilton, Ont., Canada.

[4 ] Hospices Civils de Lyon, Neurological Hospital and INSERM U821, Lyon, France.

[5 ] School of Psychology, The University of Newcastle, Callaghan, NSW, Australia.

[6 ] Department of Psychology, University of Tartu, Tartu, Estonia; Center of Functionally Integrative Neuroscience (CFIN), University of Aarhus, Aarhus, Denmark; Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland.

[7 ] Cognitive Electrophysiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA.

[8 ] Department of Psychology, University of Oslo, Oslo, Norway.

[9 ] Department of Psychology, Binghamton University, Binghamton, New York, USA.

Article

Publisher Item ID: S1388-2457(09)00518-5

DOI: 10.1016/j.clinph.2009.07.045

PubMed ID: 19796989

SO-VID: aaea6a5d-6f5b-4771-8911-fd50f275e062

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