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      Mechanisms of mechanotransduction.

      Developmental Cell

      Adaptation, Physiological, physiology, Animals, Cell Cycle, Humans, Hypertension, pathology, physiopathology, Lung, Mechanotransduction, Cellular, Models, Biological, Muscle, Smooth, Vascular, Myocardium, Neoplasms, Physical Stimulation, Protein Structure, Tertiary, Signal Transduction, Stress, Mechanical

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          Abstract

          Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.

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          Journal
          16399074
          10.1016/j.devcel.2005.12.006

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