Purpose To explore the nursing research of prostatic hyperplasia based on continuous nursing and based on the combination of medical care and nursing. Methods A prospective study of 96 patients with benign prostatic hyperplasia admitted to our hospital from November 2019 to May 2021 was selected. According to the random number table method, they were divided into an observation group and a control group with 48 cases each. The control group used routine nursing and discharge guidance, and the observation group implemented continuous care based on the combination of medical care and nursing on the basis of the control group. The differences in the scores of quality of life, self-care ability, quality of life score, and sleep quality were compared between the two groups. Results After 3 months of nursing, the quality of life scores (health status, psychology, social relationship, environment, physiology, and quality of life scores) of the observation group was higher than those of the control group (P < 0.05). After 3 months of nursing, the quality of life scores of disease, physiology, society, psychology, and satisfaction of the observation group was significantly higher than those of the control group, which was statistically significant (P < 0.05). After 3 months of nursing, the observation group's sleep quality scores in all dimensions (time to fall asleep, sleep time, sleep quality, sleep efficiency, hypnotics, sleep disorders, and day disorders) were higher than those of the control group (P < 0.05). After 3 months of nursing, the observation group's self-care skill score, self-responsibility score, health knowledge score, and self-concept score were better than those of the control group (P < 0.05). Conclusion Continued nursing care based on the combination of medical and health care for prostate hyperplasia is beneficial to improve sleep quality and improve the patient's quality of life score and self-care ability and provide certain references for clinical care of patients with benign prostatic hyperplasia.