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      The Impact of Risk Factors for Atherosclerosis on the Vasomotor Effects of Inhibition of Nitric Oxide Synthesis in Patients with Normal Angiograms

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          Abstract

          We assessed the impact of systematic risk factors on the vasomotor effects of inhibition of nitric oxide synthesis. N<sup>G</sup>-monomethyl- L-arginine (LNMMA) was infused intracoronarily at 4, 8 and 16 μmol/min followed by intracoronary bolus administration of 250 μg nitroglycerin. Computerized angiography was used to assess the changes in the diameter of coronary segments. During the LNMMA infusions there was no significant difference in LNMMA response between smokers and non-smokers (–5.5 ± 0.8 and –6.6 ± 0.6%, respectively) or between hypertensives and normotensives (–6.4 ± 1.1 and –6.1 ± 0.6%, respectively), but the response was less in hypercholesterolaemic patients (–4.5 ± 0.7 vs. –8.0 ± 0.6%, p < 0.05). Thus, the reduced nitric oxide activity is related to hypercholesterolaemia but not to smoking and hypertension.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          2000
          November 2000
          22 November 2000
          : 94
          : 1
          : 26-30
          Affiliations
          Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece; Cardiology Unit, Hammersmith Hospital, Imperial College School of Medicine, London, UK
          Article
          7042 Cardiology 2000;94:26–30
          10.1159/000007042
          11111141
          © 2000 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 2, References: 32, Pages: 5
          Categories
          General Cardiology

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