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      Factors Inducing Post-Obstructive Diuresis in Rats

      research-article
      ,
      Nephron
      S. Karger AG
      Ureteral obstructions, Post-obstructive diuresis, Urea, Extracellular fluid volume

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          Abstract

          1 day after bilateral ureteral occlusion (BUO), the extracellular fluid (ECF) volume of rats was increased by 2.8 ml/l00 g body weight above those values observed after either a sham operation or after 1 day of unilateral ureteral occlusion (UUO). The plasma urea concentration of BUO rats averaged about five times the values of either sham or UUO groups. The release of BUO of 1-day duration resulted in post-obstructive diuresis and natriuresis, whereas oliguria was observed after the release of UUO of 1-day duration. Contralateral nephrectomy of the normal kidney after the release of UUO 1-day duration (UUO-RN) resulted in an improvement of the damaged kidney functions, possibly due to an elevation of renal blood flow. Polyfructosan clearance of the UUO kidney was increased to a level significantly above the corresponding BUO value, 147 ± 34 as compared to 101 ± 8 μl/min/100 g body weight. However, post-obstructive diuresis was not observed. When the ECF volume of UUO-RN rats was elevated, towards those values observed in BUO rats by saline infusion, the rate of urine formation was insignificantly elevated above the nontreatment group, even though the sodium excretion rate was increased about three times the values of both the UUO-RN and BUO groups. When the plasma urea concentration of the UUO-RN group was elevated towards the BUO value, moderate diuresis was observed. But when both the ECF volume and plasma urea concentration of UUO-RN rats were increased towards the level of the BUO rats, post-obstructive natriuresis and diuresis were evident. Thus, the elevation of both the plasma urea concentration and the ECF volume contribute significantly to post-obstructive diuresis. However, the role of the natriuretic factors may not be eliminated due to the differences among the functioning nephrons between the BUO and UUO kidneys. The present studies were carried out to quantitate the contribution of ECF volume expansion and the elevation of plasma urea concentration on the induction of post-obstructive diuresis in rats.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          04 December 2008
          : 38
          : 2
          : 125-133
          Affiliations
          Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
          Article
          183293 Nephron 1984;38:125–133
          10.1159/000183293
          6472540
          ab4eea79-7f93-4267-a3b5-955efe8fbdab
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 20 December 1983
          Page count
          Pages: 9
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Ureteral obstructions,Post-obstructive diuresis,Urea,Extracellular fluid volume

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