Growing evidence indicates that circular RNA (circRNA) plays an important role in
the regulation of tumor biological behaviors. In this study, we aimed to explore the
role of a novel circRNA, circ_0034642, in glioma. qRT-PCR was conducted to evaluate
the levels of circ_0034642 in glioma tissues and cells. In addition, the clinical
severity and prognostic role of circ_0034642 were illustrated. Functionally, loss
and gain-of function assays were performed by CCK-8, colony-forming, flow cytometric
and transwell experiments in glioma cells. Moreover, luciferase reporter assay was
used to detect the mechanism of circ_0034642. Circ_0034642 was upregulated in glioma
tissues and cell lines. Overexpressed circ_0034642 was correlated with adverse phenotypes
in the patients with glioma. In addition, circ_0034642 could be regarded as a prognostic
predictor for glioma patients. Moreover, circ_0034642 could promote cell proliferation,
migratory and invasive capacities and inhibit cell apoptosis. For the mechanism investigation,
circ_0034642 was proved to be a sponge of miR-1205, and miR-1205 could regulate BATF3
expression via targeting 3'UTR of BATF3. Rescue assays also illustrated that the oncogenic
function of circ_0034642 is partly attributed to its modulation on miR-1205/BATF3
axis. Collectively, circ_0034642/miR-1205/BATF3 pathway may play an important role
in glioma.