For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
12
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
2 collections
    0
    shares
      1,455
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Neumonía por COVID-19 en niña con síndrome de Down Translated title: COVID-19 pneumonia in a girl with Down syndrome

      case-report

      Read this article at

      SciELO
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          RESUMEN Actualmente, no existe información estadística ni evidencias sobre cómo está afectando el SARS-CoV-2 en el síndrome de Down. Sin embargo, es frecuente que estas personas tengan comorbilidades asociadas a su síndrome como cardiopatías, enfermedad pulmonar crónica, hipertensión, diabetes u otras patologías que les hacen ser un colectivo más vulnerable. Presentamos el caso clínico de una niña de 7 meses con diagnóstico de síndrome de Down con una comunicación interauricular asociada, que padeció una neumonía por COVID-19 con una evolución tórpida y que requirió ingreso hospitalario. Es pertinente tenerlo en cuenta en nuestras consultas, dado el ambiente epidemiológico del SARS-CoV-2, puesto que son pacientes con múltiples comorbilidades que determinan factores de riesgo y mal pronóstico para esta infección.

          Translated abstract

          ABSTRACT Currently, there is no statistical information or evidence on how SARS-CoV-2 is affecting Down syndrome. However, it is common for these people to have comorbidities associated with their syndrome such as heart disease, chronic lung disease, hypertension, diabetes, or other pathologies that make them a more vulnerable group. We report the case study of a seven-month-old girl with a personal history of Down syndrome with an associated interatrial communication, who suffered from COVID-19 pneumonia with torpid clinical course and who required hospital admission. It is relevant to take this into account in our consultations, given the epidemiological environment of SARS-CoV-2, since they are patients with multiple comorbidities that determine risk factors and a poor prognosis for this infection.

          Related collections

          Most cited references12

          • Record: found
          • Abstract: found
          • Article: not found

          SARS-CoV-2 Infection in Children

          Xiaoxia Lu, Liqiong Zhang, Hui Du … (2020)
          To the Editor: As of March 10, 2020, the 2019 novel coronavirus (SARS-CoV-2) has been responsible for more than 110,000 infections and 4000 deaths worldwide, but data regarding the epidemiologic characteristics and clinical features of infected children are limited. 1-3 A recent review of 72,314 cases by the Chinese Center for Disease Control and Prevention showed that less than 1% of the cases were in children younger than 10 years of age. 2 In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Children’s Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan. Both symptomatic and asymptomatic children with known contact with persons having confirmed or suspected SARS-CoV-2 infection were evaluated. Nasopharyngeal or throat swabs were obtained for detection of SARS-CoV-2 RNA by established methods. 4 The clinical outcomes were monitored up to March 8, 2020. Of the 1391 children assessed and tested from January 28 through February 26, 2020, a total of 171 (12.3%) were confirmed to have SARS-CoV-2 infection. Demographic data and clinical features are summarized in Table 1. (Details of the laboratory and radiologic findings are provided in the Supplementary Appendix, available with the full text of this letter at NEJM.org.) The median age of the infected children was 6.7 years. Fever was present in 41.5% of the children at any time during the illness. Other common signs and symptoms included cough and pharyngeal erythema. A total of 27 patients (15.8%) did not have any symptoms of infection or radiologic features of pneumonia. A total of 12 patients had radiologic features of pneumonia but did not have any symptoms of infection. During the course of hospitalization, 3 patients required intensive care support and invasive mechanical ventilation; all had coexisting conditions (hydronephrosis, leukemia [for which the patient was receiving maintenance chemotherapy], and intussusception). Lymphopenia (lymphocyte count, <1.2×109 per liter) was present in 6 patients (3.5%). The most common radiologic finding was bilateral ground-glass opacity (32.7%). As of March 8, 2020, there was one death. A 10-month-old child with intussusception had multiorgan failure and died 4 weeks after admission. A total of 21 patients were in stable condition in the general wards, and 149 have been discharged from the hospital. This report describes a spectrum of illness from SARS-CoV-2 infection in children. In contrast with infected adults, most infected children appear to have a milder clinical course. Asymptomatic infections were not uncommon. 2 Determination of the transmission potential of these asymptomatic patients is important for guiding the development of measures to control the ongoing pandemic.
          Article 0 comments Cited 1214 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

            Jonas F. Ludvigsson (2020)
            Abstract Aim The coronavirus disease 2019 (COVID‐19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare. Methods A systematic literature review was carried out to identify papers on COVID‐19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), using the MEDLINE and Embase databases between January 1 and March 18, 2020. Results The search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1%‐5% of diagnosed COVID‐19 cases, they often have milder disease than adults and deaths have been extremely rare. Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. Elevated inflammatory markers were less common in children, and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID‐19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances. Conclusions The coronavirus disease 2019 has occurred in children, but they seemed to have a milder disease course and better prognosis than adults. Deaths were extremely rare.
            Article 0 comments Cited 1127 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study

              Haiyan Qiu, Junhua Wu, Liang Hong … (2020)
              Summary Background Since December, 2019, an outbreak of coronavirus disease 2019 (COVID-19) has spread globally. Little is known about the epidemiological and clinical features of paediatric patients with COVID-19. Methods We retrospectively retrieved data for paediatric patients (aged 0–16 years) with confirmed COVID-19 from electronic medical records in three hospitals in Zhejiang, China. We recorded patients' epidemiological and clinical features. Findings From Jan 17 to March 1, 2020, 36 children (mean age 8·3 [SD 3·5] years) were identified to be infected with severe acute respiratory syndrome coronavirus 2. The route of transmission was by close contact with family members (32 [89%]) or a history of exposure to the epidemic area (12 [33%]); eight (22%) patients had both exposures. 19 (53%) patients had moderate clinical type with pneumonia; 17 (47%) had mild clinical type and either were asymptomatic (ten [28%]) or had acute upper respiratory symptoms (seven [19%]). Common symptoms on admission were fever (13 [36%]) and dry cough (seven [19%]). Of those with fever, four (11%) had a body temperature of 38·5°C or higher, and nine (25%) had a body temperature of 37·5–38·5°C. Typical abnormal laboratory findings were elevated creatine kinase MB (11 [31%]), decreased lymphocytes (11 [31%]), leucopenia (seven [19%]), and elevated procalcitonin (six [17%]). Besides radiographic presentations, variables that were associated significantly with severity of COVID-19 were decreased lymphocytes, elevated body temperature, and high levels of procalcitonin, D-dimer, and creatine kinase MB. All children received interferon alfa by aerosolisation twice a day, 14 (39%) received lopinavir–ritonavir syrup twice a day, and six (17%) needed oxygen inhalation. Mean time in hospital was 14 (SD 3) days. By Feb 28, 2020, all patients were cured. Interpretation Although all paediatric patients in our cohort had mild or moderate type of COVID-19, the large proportion of asymptomatic children indicates the difficulty in identifying paediatric patients who do not have clear epidemiological information, leading to a dangerous situation in community-acquired infections. Funding Ningbo Clinical Research Center for Children's Health and Diseases, Ningbo Reproductive Medicine Centre, and Key Scientific and Technological Innovation Projects of Wenzhou.
              Article 0 comments Cited 586 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (publisher-id): albacete
                Title: Revista Clínica de Medicina de Familia
                Abbreviated Title: Rev Clin Med Fam
                Publisher: Sociedad Española de Medicina de Familia y Comunitaria (Barcelona, Cataluña, Spain )
                ISSN (Print): 1699-695X
                ISSN (Electronic): 2386-8201
                Publication date (Print and electronic): 2021
                Volume: 14
                Issue: 2
                Pages: 106-108
                Affiliations
                [3] orgnameSociedad Española de Medicina Familiar y Comunitaria orgdiv1Grupo de Trabajo de Genética Clínica y Cáncer Hereditario
                [1] Madrid orgnameHospital Universitario La Paz orgdiv1Consultorio El Boalo España
                [2] Madrid orgnameConsultorio El Boalo España
                Article
                Publisher ID: S1699-695X2021000200013 Publisher ID: S1699-695X(21)01400200013
                SO-VID: ab69d6a7-29e2-448c-a1bf-882bbd0bee34
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                Date accepted : 14 July 2020
                Date received : 05 May 2020
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 12, Pages: 3
                Product

                SciELO Spain

                Categories
                Subject: Un paciente con...

                Keywords: Respiratory Insufficiency,atelectasia pulmonar,COVID-19,síndrome de Down,neumonía,insuficiencia respiratoria,virus de la bronquitis infecciosa,Down Syndrome,Infectious Bronchitis Virus,Pneumonia,Pulmonary Atelectasis
                Data availability:
                Keywords: Respiratory Insufficiency, atelectasia pulmonar, COVID-19, síndrome de Down, neumonía, insuficiencia respiratoria, virus de la bronquitis infecciosa, Down Syndrome, Infectious Bronchitis Virus, Pneumonia, Pulmonary Atelectasis

                Comments

                Comment on this article