Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI.

Lukito, P; Wong, A.; Jing, J; Arthur, J F; Marasco, S F; Murphy, D A; Bergin, P J; Shaw, J. A.; Collecutt, M; Andrews, R K; Gardiner, E E; Davis, A K

doi:10.1111/jth.13497

Record: found
Abstract: found
Article: not found

Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI.

Author(s): P Lukito ¹ , A Wong ¹ , J Jing ² , J F Arthur ² , S F Marasco ³ , D A Murphy ⁴ , P J Bergin ⁵ , J A Shaw ⁵ , M Collecutt ⁶ , R K Andrews ² , E E Gardiner ⁷ , A K Davis ¹

Publication date (Electronic): November 2016

Journal: Journal of thrombosis and haemostasis : JTH

Publisher: Wiley

Keywords: extracorporeal membrane oxygenation, heart-assist devices, platelet glycoprotein Ib, platelet glycoprotein VI, von Willebrand disease

Read this article at

ScienceOpenPublisher PubMed

Bookmark

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Essentials Relationship of acquired von Willebrand disease (VWD) and platelet dysfunction is explored. Patients with ventricular assist devices and on extracorporeal membrane oxygenation are investigated. Acquired VWD and platelet receptor shedding is demonstrated in the majority of patients. Loss of platelet adhesion receptors glycoprotein (GP) Ibα and GPVI may increase bleeding risk.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): J. Thromb. Haemost.

Title: Journal of thrombosis and haemostasis : JTH

Publisher: Wiley

ISSN (Electronic): 1538-7836

ISSN (Print): 1538-7836

Publication date (Electronic): November 2016

Volume: 14

Issue: 11

Affiliations

[1 ] Haematology Unit, Alfred Hospital, Melbourne, Australia.

[2 ] Australian Centre for Blood Diseases, Monash University, Melbourne, Australia.

[3 ] Cardiothoracic Unit, Alfred Hospital, Melbourne, Australia.

[4 ] Intensive Care Unit, Alfred Hospital, Melbourne, Australia.

[5 ] Cardiology Unit, Alfred Hospital, Melbourne, Australia.

[6 ] Haematology Laboratory, Alfred Hospital, Melbourne, Australia.

[7 ] Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

Article

DOI: 10.1111/jth.13497

PubMed ID: 27601054

SO-VID: ab7df9fc-28fc-4570-960e-8a8ec11042b7

History

Keywords: platelet glycoprotein Ib,extracorporeal membrane oxygenation,heart-assist devices,platelet glycoprotein VI,von Willebrand disease

Data availability:

Keywords: platelet glycoprotein Ib, extracorporeal membrane oxygenation, heart-assist devices, platelet glycoprotein VI, von Willebrand disease

Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI.

Read this article at

Abstract

Related collections

Hearing Loss and Restoration

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 162

Cited by 30