Correlation of Entorhinal Amyloid with Memory in Alzheimer’s and Vascular but Not Lewy Body Dementia

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Abstract

Objective: To examine the relationship of the anatomic distribution of amyloid deposition to focal and global cognitive dysfunction in different subtypes of dementia. Methods: We quantified AB40 and AB42 in the temporal lobe and entorhinal cortex and examined their relationship to cognitive functions in Alzheimer’s disease (AD), vascular dementia (VaD) and dementia with Lewy bodies (DLB). Results: We found a correlation between memory impairment, but not global cognitive impairment, and amyloid load in these areas in AD and VaD but not in DLB. This relationship was stronger for AB42 and in the entorhinal cortex. Conclusion: The anatomic location of amyloid deposition is an important factor-specific factor in memory impairment in AD and VaD.

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Most cited references 2

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Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Jan Näslund (2000)

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Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

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Author and article information

Journal

Journal ID (publisher-id): DEM

Journal ID (nlm-ta): Dement Geriatr Cogn Disord

Journal ID (doi): 10.1159/issn.1420-8008

Title: Dementia and Geriatric Cognitive Disorders

Publisher: S. Karger AG

ISSN (Print): 1420-8008

ISSN (Electronic): 1421-9824

Publication date Subscription-year: 2005

Publication date (Print): February 2005

Publication date (Electronic): 11 February 2005

Volume: 19

Issue: 2-3

Pages: 57-60

Affiliations

^aInstitute for Ageing and Health, Newcastle, and ^bWolfson Centre for Age-Related Diseases, King’s College London, London, UK

Article

Publisher ID: 82349 Other ID: Dement Geriatr Cogn Disord 2005;19:57–60

DOI: 10.1159/000082349

PubMed ID: 15572872

SO-VID: ab8facd7-dc62-49a7-a758-b136ad00d2d6

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 09 May 2004

Page count

Tables: 2, References: 10, Pages: 4

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