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      British Contributions to Renal Physiology: Of Dynasties and Diuresis

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          Abstract

          British contributions to renal physiology trace back to the seminal contribution of William Bowman, who defined the structure of mammalian nephron and its blood supply and pointed out its likely mode of function. A series of contributions followed, which stemmed from a distinguished lineage of physiologists based at University College London and which had, as its high point, the establishment by Ernest H. Starling, in 1899, of a method for measuring oncotic pressure and the subsequent demonstration that glomerular filtration requires a hydrostatic pressure in excess of oncotic pressure in the glomerular capillaries. Arthur Cushny published a monograph on renal function in 1917 which had wide influence. The homeostasis of water and sodium chloride were the subjects of important contributions by Verney and De Wardener, respectively. Little contribution was made by British renal physiologists to the understanding of single nephron function with the emphasis being largely on integrative physiology.

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          Author and article information

          Journal
          AJN
          Am J Nephrol
          10.1159/issn.0250-8095
          American Journal of Nephrology
          S. Karger AG
          978-3-8055-6855-5
          978-3-318-00128-0
          0250-8095
          1421-9670
          1999
          April 1999
          23 April 1999
          : 19
          : 2
          : 257-265
          Affiliations
          Department of Medicine, Royal Free and University College Medical School, University College London, UK
          Article
          13459 Am J Nephrol 1999;19:257–265
          10.1159/000013459
          10213826
          © 1999 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 4, References: 17, Pages: 9
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/13459
          Categories
          Origins of Renal Physiology (Dedicated to Carl Gottschalk)

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