Effects of 22K or 20K Human Growth Hormone on Lipolysis, Leptin Production in Adipocytes in the Presence and Absence of Human Growth Hormone Binding Protein

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Abstract

Objective and Method: We studied the effects of human growth hormone (hGH) on leptin production and lipolysis stimulation in the presence or absence of human growth hormone binding protein (hGHBP) using 3T3- L1-hGHR adipocytes which efficiently express human growth hormone receptor. Results and Conclusion: It was clarified that (1) hGH decreases leptin secretion after hGH-induced lipolysis stimulation, and (2) the reduction of leptin production and lipolysis stimulation by 22K hGH was attenuated with hGHBP, whereas that by 20K hGH, which is a naturally occurring isoform of 22K hGH, was not affected with hGHBP.

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Growth hormone binding protein correlates strongly with leptin and percentage body fat in GH-deficient adults, is increased by GH replacement but does not predict IGF-I response

C.M. Florkowski, R. BARNARD, J.H LIVESEY … (1999)

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22-kDa and 20-kDa hGH Isoforms Show Differential-Effects When Assayed in 3T3-F442A and 3T3-F442A/C4 Adipocytes

E. Juarezaguilar, F Castromunozledo (1995)

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 2000

Publication date (Print): 2000

Publication date (Electronic): 22 June 2001

Volume: 54

Issue: 4

Pages: 203-207

Affiliations

Pharmaceuticals Group, Life Science Laboratory, Mitsui Chemicals, Inc., Mobara-shi, Chiba, Japan

Article

Publisher ID: 53260 Other ID: Horm Res 2000;54:203–207

DOI: 10.1159/000053260

PubMed ID: 11416239

SO-VID: abb94f57-140d-4e63-bb05-6e1a0325adba

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Figures: 3, References: 17, Pages: 5

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Most referenced authors 8

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