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      Interrelationship between Acetylcholine and Prostaglandins in the Control of Sodium Excretion and Renin Secretion in Anesthetized dogs. I

      , , ,

      Nephron

      S. Karger AG

      Renin, Sodium excretion, Acetylcholine, Prostaglandins

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          Abstract

          The interrelationships between acetylcholine (ACH) and prostaglandins in the control of sodium excretion (U<sub>Na</sub>V) and of renin secretion (RS) were examined in unilaterally-nephrectomized, anesthetized dogs with or without treatment with indomethacin, an inhibitor of prostaglandin synthetase. Intrarenal infusion of ACH (40 µg/min) in control animals produced diuresis and natriuresis. U<sub>Na</sub>V was 9.2 ± 3.1 µEq/min during control periods and was 74.7 ± 31.6 µEq/min after 40 min of infusion of ACH (p < 0.05). U<sub>Na</sub>V was still 48.0 ± 16.8 µEq/min after 100 min of infusion of ACH (p < 0.05). RS rate was 930.6 ± 188.5 U/min during control periods, and was 737.4 ± 220.3 U/min after 100 min of infusion of ACH (p > 0.1). In the dogs treated with indomethacin, the natriuresis produced by ACH could not be sustained. U<sub>Na</sub>V was 46.6 ± 12.1 µEq/min before and was 34.7 ± 12.8 µEq/min 100 min following the infusion of ACH (p >0.1). Arterial plasma renin activity was 3.29 ± 0.83 ng/ml/h before and was 20.97 ± 7.78 ng/ml/h after 100 min of infusion of ACH (p < 0.025). The data suggest that prostaglandins are involved in the sodium excretion and the renin secretion produced by acetylcholine.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1979
          1979
          02 December 2008
          : 23
          : 5
          : 247-254
          Affiliations
          Department of Physiology and Biophysics, Howard University, Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, Md., and Department of Physiology and Biophysics, Georgetown University, Washington, D.C.
          Article
          181644 Nephron 1979;23:247–254
          10.1159/000181644
          481661
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Prostaglandins, Acetylcholine, Sodium excretion, Renin

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