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      Use of Angiotensin-Converting Enzyme Inhibitors for the Preservation of Kidney Function

      , ,

      Nephron

      S. Karger AG

      ACE inhibitors, Enalapril, Captopril, Renal failure

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          Abstract

          To investigate the effects of angiotensin-converting enzyme (ACE) inhibitors on renal outcome in patients with renal insufficiency, a 2-part study was conducted. Part A consisted of a retrospective 1-year analysis of 80 hypertensive outpatients with serum creatinine levels of 1.5–6 mg/dl, 39 of whom received ACE inhibitors and other antihypertensive agents and 41 of whom received only other antihypertensive agents. Median serum creatinine levels in the ACE group rose acutely from 2.33 to 2.7 mg/dl after 1 month of therapy and remained stable thereafter. Serum creatinine levels more than doubled in 2 patients. In controls, median serum creatinine levels rose gradually over 12 months from 2.39 to 3.45 mg/dl, and serum creatinine more than doubled in 9 patients. Part B consisted of a prospective follow-up of patients for a second year; 34 patients in the treatment group and 32 controls were then analyzed; median serum creatinine level was 3.0 vs. 4.4 mg/dl after 2 years; 2 of 34 vs. 6 of 32 patients were on dialysis; serum creatinine level had more than doubled in 4 of 34 vs. 8 of 32. These results suggest that ACE inhibitors are more effective than other antihypertensive agents in reducing the progression of renal failure.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-5180-9
          978-3-318-01967-4
          1660-8151
          2235-3186
          1990
          1990
          16 December 2008
          : 55
          : Suppl 1
          : 38-42
          Affiliations
          Department of Medicine, University of Erlangen, Nürnberg, FRG
          Article
          186033 Nephron 1990;55:38–42
          10.1159/000186033
          2345591
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

          ACE inhibitors, Enalapril, Captopril, Renal failure

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