+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Altered Membrane Electrical Properties of Smooth Muscle Cells from Small Cerebral Arteries of Hypertensive Rats


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Certain electrophysiological properties of smooth muscle cells within middle cerebral arteries of spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto (WKY) controls were recorded with glass microelectrodes. Under control conditions the smooth muscle cells of arteries from SHR rats exhibited fast and slow oscillations of the resting membrane potential (E<sub>m</sub>). In marked contrast the smooth muscle cells of WKY cerebral arteries were electrically quiescent. The E<sub>m</sub> vs. log [K]o relationship was similar for arteries from both SHR and WKY rats and extrapolated to similar [K]i values of 150–155 mM when determined under control conditions. When E<sub>m</sub> vs. log [K]o curves were obtained in the presence of ouabain to block electrogenic Na-K transport, the smooth muscle cells of SHR cerebral arteries exhibited a lower mean slope per decade change in [K]o (i.e., depolarized more at various concentrations of [Ko in the presence of ouabain) when compared to WKY. Arterial smooth muscle cells from SHR also depolarized to a greater extent when exposed to zero K<sup>+</sup> solutions. The results of this study indicate that smooth muscle cells of cerebral arteries from SHR rats have a greater electrogenic E<sub>m</sub> component as well as altered ionic conductances for K<sup>+</sup> and possibly Na<sup>+</sup> both of which may contribute to their spontaneous electrical activity.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 20
          : 3
          : 154-160
          Department of Physiology and Biophysics, College of Medicine, University of Vermont, Burlington, Vt., USA
          158469 Blood Vessels 1983;20:154–160
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Research Paper


          Comment on this article