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      The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations.

      Critical reviews in oncogenesis
      Animals, Cell Transformation, Neoplastic, genetics, Cocarcinogenesis, Humans, Mice, Neoplasms, physiopathology, Transforming Growth Factor beta, physiology, Wound Healing

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          Abstract

          From clinical, chemical carcinogenesis and transgenic animal studies, it is evident that wounding has a tumor-promoting effect. We discuss the role of TGF-beta (with special emphasis on TGF-beta 1) in this process and suggest that stromal alterations during wound healing, induced by TGF-beta, can be an important determinant of tumor growth. A tumor and a wound both require similar stromal microenvironments. Thus, a chemically initiated or an oncogene-expressing cell could be complemented to grow into a tumor if it finds itself in a hospitable wound-healing stroma.

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