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      Modification of Spherical Polyelectrolyte Brushes by Layer-by-Layer Self-Assembly as Observed by Small Angle X-ray Scattering

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          Abstract

          Multilayer modified spherical polyelectrolyte brushes were prepared through alternate deposition of positively charged poly(allylamine hydrochloride) (PAH) and negatively charged poly- l-aspartic acid (PAsp) onto negatively charged spherical poly(acrylic acid) (PAA) brushes (SPBs) on a poly(styrene) core. The charge reversal determined by the zeta potential indicated the success of layer-by-layer (LBL) deposition. The change of the structure during the construction of multilayer modified SPBs was observed by small-angle X-ray scattering (SAXS). SAXS results indicated that some PAH chains were able to penetrate into the PAA brush for the PAA-PAH double-layer modified SPBs whereas part of the PAH moved towards the outer layer when the PAsp layer was loaded to form a PAA-PAH-PAsp triple-layer system. The multilayer modified SPBs were stable upon changing the pH (5 to 9) and ionic strength (1 to 100 mM). The triple-layer modified SPBs were more tolerated to high pH (even at 11) compared to the double-layer ones. SAXS is proved to be a powerful tool for studying the inner structure of multilayer modified SPBs, which can establish guidelines for the a range of potential applications of multilayer modified SPBs.

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          Thermosensitive core-shell particles as carriers for ag nanoparticles: modulating the catalytic activity by a phase transition in networks.

          Matthias Ballauff, Markus Drechsler, Yu Mei … (2006)
          Article 0 comments Cited 134 times – based on 0 reviews     Review now
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            Polymeric multilayer capsules in drug delivery.

            Johan Grooten, José Filho, Jean Paul Remon … (2010)
            Recent advances in medicine and biotechnology have prompted the need to develop nanoengineered delivery systems that can encapsulate a wide variety of novel therapeutics such as proteins, chemotherapeutics, and nucleic acids. Moreover, these delivery systems should be "intelligent", such that they can deliver their payload at a well-defined time, place, or after a specific stimulus. Polymeric multilayer capsules, made by layer-by-layer (LbL) coating of a sacrificial template followed by dissolution of the template, allow the design of microcapsules in aqueous conditions by using simple building blocks and assembly procedures, and provide a previously unmet control over the functionality of the microcapsules. Polymeric multilayer capsules have recently received increased interest from the life science community, and many interesting systems have appeared in the literature with biodegradable components and biospecific functionalities. In this Review we give an overview of the recent breakthroughs in their application for drug delivery.
            Article 0 comments Cited 91 times – based on 0 reviews     Review now
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              Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs.

              Thiruganesh Ramasamy, Ziyad S Haidar, Tuan Tran … (2014)
              Layer-by-layer (LbL)-engineered nanoparticles (NPs) are a promising group of therapeutic carriers used in an increasing number of biomedical applications. The present study uses a controlled LbL process to create a multidrug-loaded nanoplatform capable of promoting blood circulation time, biodistribution profile and controlling drug release in the dynamic systemic environment. LbL assembly is achieved by sequential deposition of poly-l-lysine (PLL) and poly(ethylene glycol)-block-poly(l-aspartic acid) (PEG-b-PLD) on liposomal nanoparticles (LbL-LNPs). This generates spherical and stable multilayered NPs ∼240nm in size, enabling effective systemic administration. The numerous functional groups and compartments in the polyelectrolyte shell and core facilitate loading with doxorubicin and mitoxantrone. The nanoarchitecture effectively controls burst release, providing different release kinetics for each drug. LbL-LNPs are pH-sensitive, indicating that intracellular drug release can be increased by the acidic milieu of cancer cells. We further demonstrate that the LbL nanoarchitecture significantly reduces the elimination rates of both drugs tested and markedly extends their systemic circulation times, paving the way for efficacious tumor drug delivery. Because this delivery system accommodates multiple drugs, improves drug half-life and diminishes burst release, it provides an exciting platform with remarkable potential for combination therapeutics in cancer therapy.
              Article 0 comments Cited 69 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Christine Wandrey: Role: Academic Editor
                Ruth Freitag: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Polymers (Basel)
                Journal ID (iso-abbrev): Polymers (Basel)
                Journal ID (publisher-id): polymers
                Title: Polymers
                Publisher: MDPI
                ISSN (Electronic): 2073-4360
                Publication date (Electronic): 15 April 2016
                Publication date Collection: April 2016
                Volume: 8
                Issue: 4
                Electronic Location Identifier: 145
                Affiliations
                [1 ]State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China; tianyuchuanecust@ 123456163.com (Y.T.); 020120096@ 123456mail.ecust.edu.cn (H.H.); wang88101500@ 123456163.com (W.W.); Y20140094@ 123456mail.ecust.edu.cn (Y.W.); 18817507593@ 123456163.com (Z.Y.)
                [2 ]Engineering Research Center of Xinjiang Bingtuan of Materials Chemical Engineering, Shihezi University, Xinjiang 832000, China
                Author notes
                [* ]Correspondence: lili76131@ 123456ecust.edu.cn (L.L.); guoxuhong@ 123456ecust.edu.cn (X.G.); Tel.: +86-21-6425-3789 (L.L.); +86-21-6425-3491 (X.G.)
                Article
                Publisher ID: polymers-08-00145
                DOI: 10.3390/polym8040145
                PMC ID: 6432364
                SO-VID: abf10880-47fd-4645-b5c9-b3207ddce16f
                Copyright © © 2016 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 31 January 2016
                Date accepted : 08 April 2016
                Categories
                Subject: Article

                Keywords: spherical polyelectrolyte brushes,layer-by-layer deposition,small x-ray scattering
                Data availability:
                Keywords: spherical polyelectrolyte brushes, layer-by-layer deposition, small x-ray scattering

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