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      Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates.

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          Abstract

          Overexpression of hyaluronan (HA) receptors on cancer cells results in enhanced endocytotic uptake of the drug conjugate. An N-(2-hydroxypropyl)methacrylamide (HPMA)-HA polymeric drug delivery system was used for targeted delivery of doxorubicin to cancer cells.

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          Author and article information

          Journal
          Pharm Res
          Pharmaceutical research
          Springer Science and Business Media LLC
          0724-8741
          0724-8741
          Apr 2002
          : 19
          : 4
          Affiliations
          [1 ] Department of Medicinal Chemistry, The University of Utah, Salt Lake City, USA.
          Article
          10.1023/a:1015170907274
          12033370
          abf76bdc-87ff-405c-985e-b4f01cf8d7e6
          History

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