Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

An integrative theory of prefrontal cortex function.

Annual review of neuroscience

physiology, Prefrontal Cortex, Neurons, Neural Pathways, Models, Neurological, Memory, Humans, Cognition, Attention, Animals

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task. We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed

      Related collections

      Author and article information

      Journal
      10.1146/annurev.neuro.24.1.167
      11283309

      Comments

      Comment on this article