13
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Association of Corrected QT and QT Dispersion with Echocardiographic and Laboratory Findings in Uremic Patients under Chronic Hemodialysis

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Introduction:

          Cardiovascular disease is the most common cause of mortality in dialysis patients. Chronic renal failure and hemodialysis (HD) patients may have longer corrected QT (QTc) interval compared with the normal population. Long QTc interval may be a predictor of ventricular arrhythmia and cardiovascular mortality in these patients and hence the aim of this study was the evaluation of the relationship between QTc interval and some echocardiographic findings and laboratory exam results in HD patients.

          Materials and Methods:

          In a cross-sectional study, 60 HD patients with age >18 years and the dialysis duration >3 months were enrolled. Blood samples were taken, and electrocardiography and echocardiography were done before the dialysis session in the patients.

          Results:

          Mean age of the patients was 56.15 ± 14.6 years. QTc interval of the patients was 0.441 ± 0.056 s and QT dispersion (QTd) was 64.17 ± 25.93 ms. There was no statistically significant relationship between QTc interval and QTd with duration of dialysis, body mass index, age, and gender ( P > 0.05). There was also no significant relationship between QTc interval and QTd with mitral regurgitation, tricuspid regurgitation and aortic insufficiency ( P > 0.05). In addition, QTc interval and QTd of the patients had not any correlation with serum parathormon and serum Ca, K, HCO 3 ( P > 0.05).

          Conclusion:

          Based on our results, in HD patients, QTc interval and QTd were not correlated with echocardiographic findings or laboratory exam results. Therefore, it can be concluded that QTc interval prolongation probably has not any correlation with cardiac mortality of the HD patients.

          Related collections

          Most cited references29

          • Record: found
          • Abstract: found
          • Article: not found

          Chronic kidney disease and mortality risk: a systematic review.

          Current guidelines identify people with chronic kidney disease (CKD) as being at high risk for cardiovascular and all-cause mortality. Because as many as 19 million Americans may have CKD, a comprehensive summary of this risk would be potentially useful for planning public health policy. A systematic review of the association between non-dialysis-dependent CKD and the risk for all-cause and cardiovascular mortality was conducted. Patient- and study-related characteristics that influenced the magnitude of these associations also were investigated. MEDLINE and EMBASE databases were searched, and reference lists through December 2004 were consulted. Authors of 10 primary studies provided additional data. Cohort studies or cohort analyses of randomized, controlled trials that compared mortality between those with and without chronically reduced kidney function were included. Studies were excluded from review when participants were followed for < 1 yr or had ESRD. Two reviewers independently extracted data on study setting, quality, participant and renal function characteristics, and outcomes. Thirty-nine studies that followed a total of 1,371,990 participants were reviewed. The unadjusted relative risk for mortality in participants with reduced kidney function compared with those without ranged from 0.94 to 5.0 and was significantly more than 1.0 in 93% of cohorts. Among the 16 studies that provided suitable data, the absolute risk for death increased exponentially with decreasing renal function. Fourteen cohorts described the risk for mortality from reduced kidney function, after adjustment for other established risk factors. Although adjusted relative hazards were consistently lower than unadjusted relative risks (median reduction 17%), they remained significantly more than 1.0 in 71% of cohorts. This review supports current guidelines that identify individuals with CKD as being at high risk for cardiovascular mortality. Determining which interventions best offset this risk remains a health priority.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Electrocardiographic abnormalities and uremic cardiomyopathy.

            Progressive renal disease is associated with an increased risk of cardiovascular death, specifically sudden death. We investigated the link between uremic cardiomyopathy, QT interval and dispersal, and arrhythmias (by ambulatory ECG monitoring) in patients at different stages of progressive renal disease. In a cross-sectional study we investigated 296 patients with nondiabetic renal disease (53 transplant recipients, 55 hemodialysis patients, and 188 throughout the range of chronic renal failure). Patients underwent echocardiography, ECG, and ambulatory blood pressure and ECG monitoring. Left ventricular mass was increased from the earliest stages of renal disease (near-normal renal function), the predominant pattern being eccentric left ventricular hypertrophy (LVH). There was a progressive increase in LVH with loss of renal function, so that more than 80% of patients on renal replacement therapy have LVH, the dominant pattern being concentric LVH. The prevalence of diastolic dysfunction increased in parallel with changes in left ventricular mass but systolic dysfunction and ventricular dilatation did not. Increased QT interval and QT dispersal were associated with poor renal function (maximal in dialysis patients), and were linked to LVH and other echocardiographic abnormalities. Arrhythmias were uncommon on ambulatory recording but were more common with poor renal function, in the presence of uremic cardiomyopathy, and increased QT interval and dispersal. LVH is present from the earliest stages of progressive renal disease. This, and other forms of uremic cardiomyopathy, is linked to increased QT interval and dispersal, and with minor rhythm abnormalities, providing a link with the high risk of sudden death in this population.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The acute cardiac effects of dialysis.

              It is well recognized that the procedure of hemodialysis is associated with significant changes in blood pressure and systemic hemodynamics; 20-30% of treatments are complicated by intradialytic hypotension (IDH). There are now an increasing number of studies using electrocardiographic, isotopic and echocardiographic techniques that show that subclinical myocardial ischemia occurs during dialysis. This concept is supported by some studies showing that dialysis can induce acute rises in troponins and creatinine kinase MB, although this has not been found by all authors. Some of this controversy may at least in part be due to the collection of blood samples immediately postdialysis, which is likely to be too early to reliably detect dialysis-induced elevations of cardiac enzymes. Cardiovascular death is the biggest single cause of mortality in dialysis patients and of this sudden death comprises the largest proportion. As such, there is a large body of evidence examining whether dialysis is pro-arrhythmogenic. It is clear that dialysis can increase QTc interval and QT dispersion and is capable of inducing arrhythmias on Holter monitoring, likely due to the interaction of multiple factors, some of which prime for the development of arrhythmias (particularly the presence of preexisting cardiac disease), and some of which act as triggers. However, the link between these electrocardiographic alterations and sudden death is relatively poorly studied. This review summarizes the available literature regarding the acute cardiac effects of dialysis in relation to the above, and discusses how these acute changes may contribute to the genesis of uremic cardiomyopathy and longer term cardiac outcomes.
                Bookmark

                Author and article information

                Journal
                J Cardiovasc Ecogr
                J Cardiovasc Ecogr
                JCE
                Journal of Cardiovascular Echography
                Medknow Publications & Media Pvt Ltd (India )
                2211-4122
                2347-193X
                Jul-Sep 2014
                : 24
                : 3
                : 78-82
                Affiliations
                [1] Department of Internal Medicine, Nephrology Division, Shahrekord University of Medical Sciences, Iran
                [1 ] Department of Internal Medicine, Nephrology Division, Shahrekord University of Medical Sciences, Iran
                [2 ] Department of Epidemiology and Biostatistics, Social Health Determinants Research Center, Shahrekord University of Medical Sciences, Iran
                [3 ] Department of Biostatistics and Epidemiology, School of Health, Shahrekord University of Medical Sciences, Iran
                Author notes
                Address for correspondence Dr. Ali Momeni, Department of Internal Medicine, Hajar Hospital, Shahrekord, Iran. E-mail: dr.ali_momeny@ 123456yahoo.com
                Article
                JCE-24-78
                10.4103/2211-4122.143972
                5353447
                ac236cfc-d87c-45e7-90c1-b16f20db1481
                Copyright: © 2014 Journal of Cardiovascular Echography

                This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

                History
                Categories
                Original Article

                corrected qt interval,echocardiography,hemodialysis,qt dispersion

                Comments

                Comment on this article