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      European Experience with Artex: The Tertatolol International Multicentre Study (TIMS)

      Cardiology

      S. Karger AG

      Tertatolol, Beta-blockers, Hypertension

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          Abstract

          The Tertatolol International Multicentre Study (TIMS) was aimed at assessing the efficacy and acceptability of 5 mg tertatolol (T) once daily over a 1-year period. The study was carried out in 230 patients (96 men, 134 women, mean age 51.5 ± 0.7 years) with uncomplicated mild-to-moderate hypertension. After a 1-month placebo run-in period followed by a 1-month double blind placebo-controlled period, 213 patients entered and 166 completed the 1-year open period. A diuretic (D) was added if blood pressure (BP) was inadequately controlled with tertatolol alone. After 1 year, 88.5% of patients were controlled (sitting diastolic BP ≤ 90mmHg): 56.3% on single therapy (T) and 32.2% on dual therapy (T + D), respectively. After a 1-month double-blind period, the incidence of emergent symptoms was not significantly different between the placebo group and the tertatolol group. This low incidence was also observed over the 1-year period, side effects leading to the discontinuation of the treatment in 9.1% of the cases. In patients whose creatinine level was initially higher than 100µmol/l, tertatolol significantly decreased creatinine level in the single but not in the dual therapy group. This study confirms that tertatolol is an efficient and well-tolerated antihypertensive drug, which improves renal function.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-5869-3
          978-3-318-01965-0
          0008-6312
          1421-9751
          1993
          1993
          18 November 2008
          : 83
          : Suppl 1
          : 25-31
          Affiliations
          The James Connolly Memorial Hospital, Dublin, Ireland
          Article
          176007 Cardiology 1993;83:25–31
          10.1159/000176007
          7903212
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
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