+1 Recommend
0 collections
      • Record: found
      • Abstract: found
      • Article: not found

      [IGF(s) and testicular functions. Secretion and action of IGF-1 on Leydig cells].

      Contraception, fertilité, sexualité (1992)

      Animals, Chorionic Gonadotropin, physiology, Follicle Stimulating Hormone, Insulin-Like Growth Factor I, Leydig Cells, Luteinizing Hormone, Male, Rats, Testis

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Many in vitro and in vivo studies have demonstrated a presence of IGF-I in the testis. Testicular production of IGF-I and its mRNA is stimulated largely by gonadotropins; FSH acts on Sertoli cells while LH acts on Leydig cells. A regulation by local factors is also demonstrated; the role of GH remains unclear. In the testis, IGF-I has various effects but we only focussed this review on Leydig cells. Specific receptors have been characterized on these cells. They are up-regulated by LH/hCG (at the transcriptional level) and down regulated by IGF-I. The effect of GH is depend on the experimental models used. In addition in this paper, we have shown in adult rats that the IGF-I level in the testicular interstitial fluid and the IGF-I receptors on Leydig cells are modified by fasting. Both in vivo and in vitro, IGF-I increased LH/hCG receptors and the steroïdogenic response to hCG by a mechanism which is poorly understood yet.

          Related collections

          Author and article information



          Comment on this article