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      Bactericidal mechanism of nanopatterned surfaces.

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      Physical chemistry chemical physics : PCCP
      Royal Society of Chemistry (RSC)

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          Abstract

          The quest to design and fabricate new antibacterial surfaces is an important task to meet the urgent demands of biomedical applications. Recently, a mechanical mechanism for killing adherent bacteria was discovered on nanopatterned surfaces, but there is a lack of understanding of the bactericidal mechanism. Here we present a quantitative thermodynamic model to study the bactericidal mechanism of nanopatterned surfaces through analyzing the total free energy change of bacterial cells. By comparing the bacterial cells on a flat surface and nanopatterned surface, our theoretical results reveal that cicada wing-like nanopatterned surfaces have more effective bactericidal properties than flat surfaces because a patterned surface leads to a drastic increase of the contact adhesion area. Our model also reveals some details of the influence mechanism, and gives some important information about how to improve the bactericidal properties through designing the morphology of the patterned surface.

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          Author and article information

          Journal
          Phys Chem Chem Phys
          Physical chemistry chemical physics : PCCP
          Royal Society of Chemistry (RSC)
          1463-9084
          1463-9076
          Jan 14 2016
          : 18
          : 2
          Affiliations
          [1 ] MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, P. R. China. xlli@scnu.edu.cn.
          Article
          10.1039/c5cp05646b
          26661138
          ac5bf6f5-2bec-46ba-b23c-a06ae66b0d64

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