Objective To explore the characteristics and related factors of low-risk human papilloma virus (HPV) infection among HPV-positive women in Shenzhen.
Methods Women who participated in HPV testing for cervical cancer screening and then detected HPV positive between 2014 and 2016 were observed. Chi-square tests were used for analyzing low-risk HPV distribution among different subgroups of women. An unconditional logistic regression model was applied to explore the related factors of low-risk HPV infection.
Results Totally 10 624 HPV-positive women were included in the analysis, in which 1 077 women were detected with low-risk HPV infection (10.1%). The proportions of different low-risk HPV genotypes were HPV 43 (3.3%), HPV 6 (2.6%), HPV 42 (2.3%), HPV 11 (2.0%), HPV 44 (0.4%), and HPV 81 (0.1%), from high to low. Except for nationality, the distributions of low-risk HPV infection varied significantly when stratified by age, occupation, marital status, screening types and years, and high-risk HPV 16/18 infected status ( P<0.05). Multivariate logistic regression analysis showed that compared with women younger than 25 years old, women in other age groups had decreased risks of low-risk HPV infection; single/divorced/widowed women had a increased risk of low-risk HPV infection than women who got married [ OR (95% CI): 1.91 (1.47-2.47)]; women infected by HPV 16 /18 had a decreased risk of low-risk HPV infection than uninfected individuals [ OR (95% CI): 0.25 (0.20-0.31)].
Conclusion From 2014 to 2016, HPV 43 was the most common low-risk HPV genotype for women infected by HPV in Shenzhen area. Age, marital status, and high-risk HPV 16/18 infected status were associated factors for low-risk HPV infection.
摘要： 目的 了解深圳市女性人乳头瘤病毒 (human papilloma virus, HPV) 阳性者低危型感染型别分布特征。 方法 以深圳地区2014—2016年参与子宫颈癌筛查的女性为研究对象, 分析HPV检测阳性且HPV基因分型检测为低 危型的HPV感染型别分布, 采用 χ 2检验进行组间比较, 并利用非条件logistic回归模型探讨低危型HPV感染的相关因 素。 结果共10 624例HPV阳性者纳入型别分析, 感染低危型HPV者共1 077例, 占10.1%。不同低危型别感染按比 例高到低分别为HPV 43 (3.3%) 、HPV 6 (2.6%) 、HPV 42 (2.3%) 、HPV 11 (2.0%) 、HPV 44 (0.4%) 和HPV 81 (0.1%) 。除民 族外, 不同年龄、职业、婚姻状况、筛查形式、筛查年份及高危型HPV 16/18感染状态者低危型HPV感染比例分布差异有 统计学意义 ( P<0.05) 。多因素Logistic回归分析结果显示, 以25岁及以下者为参照, 其他高年龄组发生低危型HPV感 染的风险降低; 以已婚者为参照, 未婚/离异/丧偶者发生低危型HPV感染的风险更高 ( OR 和95% CI：1.91, 1.47~ 2.47) ; 与无高危型HPV 16/18者相比, 感染高危型HPV 16/18者发生低危型HPV感染的风险降低 ( OR 和95% CI：0.25, 0.20~0.31) 。 结论2014—2016年深圳地区女性HPV阳性者低危型别感染以HPV 43最为常见, 年龄、婚姻状况、高危型 HPV 16/18感染可能是低危型HPV感染的相关因素。