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      d -Serine is a potential biomarker for clinical response in treatment of post-traumatic stress disorder using ( R , S )-ketamine infusion and TIMBER psychotherapy: A pilot study

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      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
      Elsevier BV

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          Abstract

          Post-traumatic stress disorder (PTSD) is a chronic and debilitating condition that is often refractory to standard frontline antidepressant therapy. A promising new approach to PTSD therapy is administration of a single sub-anesthetic dose of (R,S)-ketamine (Ket). The treatment produces rapid and significant therapeutic response, which lasts for only 4-7 days. In one of our studies, the mean duration of response was increased to 33 days when Ket administration was combined with a mindfulness-based cognitive therapy, Trauma Interventions using Mindfulness Based Extinction and Reconsolidation (TIMBER). We now report the results from a 20-patient study, which examined the duration of sustained response with combined TIMBER-Ket therapy, TIMBER-K arm, relative to the response observed in a placebo-controlled arm, TIMBER-P. A significant difference in the duration of response was observed between TIMBER-K and TIMBER-P arms: 34.44 ± 19.12 days and 16.50 ± 11.39 days, respectively (p = 0.022). Previous studies identified a negative correlation between antidepressant response to Ket and basal plasma concentrations of d-serine (DSR). In this study, the basal DSR levels positively correlated with the pre-treatment severity of PTSD symptoms (Pearson's r = 0.42, p = 0.07) and patients with basal DSR level ≥ 3.5 μM displayed not only higher PTSD severity but also shorter duration of response. The data indicate that basal DSR levels may serve as a biomarker of the severity of PTSD symptoms and as a predictor of clinical response. This article is part of a Special Issue entitled: d-Amino acids: biology in the mirror, edited by Dr. Loredano Pollegioni, Dr. Jean-Pierre Mothet and Dr. Molla Gianluca.

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          Author and article information

          Journal
          Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
          Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
          Elsevier BV
          15709639
          July 2018
          July 2018
          : 1866
          : 7
          : 831-839
          Article
          10.1016/j.bbapap.2018.03.006
          29563072
          ac6f9641-7689-4253-a473-d8e417c16b8c
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/


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