+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Role of Regional Changes in Ventricular Performance in the Hypodynamic State Induced hy Acute Coronary Occlusion

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Short-term coronary ischemia was produced in dogs anesthetized with pentothal by ligating the left anterior descending coronary artery. The resulting changes in representative hemodynamic parameters and the patterns of segmental contraction within and outside the ischemic area were recorded. Two types of reaction to coronary ligation were obtained: in some animals the contractility of the ischemic area rapidly decreased, leading to ballooning of the cardiac wall, inversion of the segmental contraction trace, marked reduction in stroke volume, pronounced increase in ventricular end-diastolic volume, and significant reduction in rate of intra-ventricular pressure rise (dP/dt). In other animals there were no signs of functional ventricular aneurysm, the changes in ventricular end-diastolic volume were less marked, and dP/dt was not altered to a significant extent. These observations suggest that in these cases characterized by the development of a functional aneurysm, the decrease in stroke volume does not result solely from dilation of the entire left ventricle, but also from the increased requirement for systolic fiber shortening in the viable myocardium, which must compensate for the extra stretch in the aneurysmal portion of the ventricular wall. It is suggested that diminution of stroke volume is due not only to the increase in wall stress in the whole left ventricle; it owes also to the expending of contractile elements in the viable portion of the muscle to compensate for additional elasticity in the functional left ventricular aneurysm.

          Related collections

          Author and article information

          S. Karger AG
          29 October 2008
          : 58
          : 4
          : 238-250
          Institute of Cardiology (Director: Prof. Z. Askanas), Medical Academy, Warsaw
          169639 Cardiology 1973;58:238–250
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13


          Comment on this article