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In vivo time-gated diffuse correlation spectroscopy at quasi-null source-detector separation.
M Pagliazzi ,
S Konugolu Venkata Sekar ,
L Di Sieno ,
L Colombo ,
T Durduran ,
D Contini ,
A Torricelli ,
A Pifferi ,
A Dalla Mora
Jun 01 2018
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Abstract
We demonstrate time domain diffuse correlation spectroscopy at quasi-null source-detector separation by using a fast time-gated single-photon avalanche diode without the need of time-tagging electronics. This approach allows for increased photon collection, simplified real-time instrumentation, and reduced probe dimensions. Depth discriminating, quasi-null distance measurement of blood flow in a human subject is presented. We envision the miniaturization and integration of matrices of optical sensors of increased spatial resolution and the enhancement of the contrast of local blood flow changes.