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      Telomerase: a target for cancer therapeutics.

      Cancer Cell
      Animals, Antineoplastic Agents, metabolism, pharmacology, therapeutic use, Cell Division, drug effects, Cell Transformation, Neoplastic, Drug Design, Enzyme Inhibitors, Forecasting, Humans, Immunotherapy, Models, Biological, Neoplasms, diagnosis, enzymology, therapy, Oligonucleotides, Antisense, RNA, Catalytic, Reverse Transcriptase Inhibitors, Telomerase, antagonists & inhibitors, genetics, Telomere, chemistry

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          Abstract

          The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.

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