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Magnetic resonance angiography using gadolinium-based molecular contrast agents suffers
from short diagnostic window, relatively low resolution and risk of toxicity. Taking
into account the chemical exchange between metal centers and surrounding protons,
magnetic nanoparticles with suitable surface and interfacial features may serve as
alternative T1 contrast agents. Herein, we report the engineering on surface structure
of iron oxide nanoplates to boost T1 contrast ability through synergistic effects
between exposed metal-rich Fe3O4(100) facets and embedded Gd2O3 clusters. The nanoplates
show prominent T1 contrast in a wide range of magnetic fields with an ultrahigh r1
value up to 61.5 mM(-1) s(-1). Moreover, engineering on nanobio interface through
zwitterionic molecules adjusts the in vivo behaviors of nanoplates for highly efficient
magnetic resonance angiography with steady-state acquisition window, superhigh resolution
in vascular details, and low toxicity. This study provides a powerful tool for sophisticated
design of MRI contrast agents for diverse use in bioimaging applications.
†State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory
for Chemical Biology of Fujian Province, and Department of Chemical Biology, College
of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
‡National Engineering Research Center for Biomaterials, and Department of Radiology,
West China Hospital, Sichuan University, Chengdu 610064, China.